The Cochrane Methodology Register (CMR) is a bibliography of publications that report on methods used in the conduct of controlled trials. It includes journal articles, books, and conference proceedings, and the content is sourced from MEDLINE and hand searches. CMR contains studies of methods used in reviews and more general methodological studies that could be relevant to anyone preparing systematic reviews. CMR records contain the title of the article, information on where it was published (bibliographic details), and, in some cases, a summary of the article. They do not contain the full text of the article.
The CMR was produced by the Cochrane UK, until 31st May 2012. There are currently no plans to reinstate the CMR and it is not receiving updates.* If you have any queries, please contact the Cochrane Community Service Team (support@cochrane.org).
The Publishers, John Wiley & Sons Ltd, thanks Update Software for the continued use of their data formats in the Cochrane Methodology Register (CMR).
*Last update in January 2019.
| Title | Sample size calculations in studies of test accuracy |
| Authors | Obuchowski NA |
| Source | Statistical Methods in Medical Research |
| Date of publication | 1998 |
| Volume | 7 |
| Issue | 4 |
| Pages | 371-392 |
| Abstract | Methods for determining sample size for studies of the accuracy of diagnostic tests are reviewed. Several accuracy indices are considered, including sensitivity and specificity, the full and partial area under the receiver operating characteristic curve, the sensitivity at a fixed false positive rate, and the likelihood ratio. Sample size formulae are presented for studies evaluating a single test and studies comparing the accuracy of tests. Four real examples illustrate the concepts involved in sample size determination. Lastly, various study design issues are discussed, such as sampling methods, choices in format for the test results, and the issue of replicated readings |
| CMR keywords | B1;C7;CMR: Evaluation methodology - diagnostic test accuracy - general;CMRA4 |
| Correspondence address | Department of Biostatistics and Epidemiology, Cleveland Clinic Foundation, OH 44195-5196, USA. nobuchow@bio.ri.ccf.org |
| Reference type | Journal article |