The Cochrane Methodology Register (CMR) is a bibliography of publications that report on methods used in the conduct of controlled trials. It includes journal articles, books, and conference proceedings, and the content is sourced from MEDLINE and hand searches. CMR contains studies of methods used in reviews and more general methodological studies that could be relevant to anyone preparing systematic reviews. CMR records contain the title of the article, information on where it was published (bibliographic details), and, in some cases, a summary of the article. They do not contain the full text of the article.
The CMR was produced by the Cochrane UK, until 31st May 2012. There are currently no plans to reinstate the CMR and it is not receiving updates.* If you have any queries, please contact the Cochrane Community Service Team (support@cochrane.org).
The Publishers, John Wiley & Sons Ltd, thanks Update Software for the continued use of their data formats in the Cochrane Methodology Register (CMR).
*Last update in January 2019.
| Title | Longitudinal data analysis (repeated measures) in clinical trials |
| Authors | Albert PS. |
| Source | Statistics in Medicine |
| Date of publication | 1999 Jul 15 |
| Volume | 18 |
| Issue | 13 |
| Pages | 1707-1732 |
| Abstract | Longitudinal data is often collected in clinical trials to examine the effect of treatment on the disease process over time. This paper reviews and summarizes much of the methodological research on longitudinal data analysis from the perspective of clinical trials. We discuss methodology for analysing Gaussian and discrete longitudinal data and show how these methods can be applied to clinical trials data. We illustrate these methods with five examples of clinical trials with longitudinal outcomes. We also discuss issues of particular concern in clinical trials including sequential monitoring and adjustments for missing data. A review of current software for analysing longitudinal data is also provided. Published in 1999 by John Wiley & Sons, Ltd. This article is a US Government work and is the public domain in the United States. |
| CMR keywords | CMR: Meta-analysis - different endpoints;CMRA6.1 |
| Correspondence address | Biometric Research Branch, National Cancer Institute, CTEP, DCTDC Executive Plaza North, 6130 Executive Blvd, MSC 7434 Bethesda, MD 20892-7434, USA. |
| Reference type | Journal article |